Researchers in Canada have identified an unsuspected role of a protein named SHP-1 in controlling blood glucose that could constitute a new therapeutic path against Type 2 Diabetes. It is known that SHP-1 plays a role in regulating the immune system, but the researchers verified if this protein was involved in the regulation of metabolism. The study involved a series of genetically modified mice producing little or no SHP-1 indicated extreme sensitivity to insulin and, consequently, they are very effective in metabolizing glucose at the level of the liver and the muscles. SHP-1 inhibits the decomposition of insulin by the liver which could explain the increase in the insulin concentrations of
certain metabolic disorders associated with obesity.
It would perhaps be possible to restore better control of blood glucose by inhibiting the activity of SHP-1. But the difficulty is to reach that point without blocking the essential part played by this protein in the immune system. Although
SHP-1 protein is present in humans, its role in the regulation of the metabolism of glucose and in the development of Type 2 Diabetes remains to be shown. But considering the findings in the study, this could lead to further research regarding diabetes.
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Tracked: Oct 08, 14:30